Recent technologies proceed the remarkable development of genetical and protein analysis. However, we are apt to lose opportunities to observe about the disease as a whole feature. In this article, we describe the inflammatory process from synovial inflammation to cartilage and bone destruction. We notice that there are many problems to be solved in rheumatoid arthritis (RA) from the point of inflammatory process. It is often needed for us to stand still and look over the whole features of disease.