TOR and aging: less is more

Stefan M Schieke; Toren Finkel

doi:10.1016/j.cmet.2007.03.005

TOR and aging: less is more

Cell Metab. 2007 Apr;5(4):233-5. doi: 10.1016/j.cmet.2007.03.005.

Authors

Stefan M Schieke¹, Toren Finkel

Affiliation

¹ Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 17403368
DOI: 10.1016/j.cmet.2007.03.005

Abstract

Metabolism and mitochondrial activity are thought to be important determinants of life span. A new study in this issue of Cell Metabolism (Bonawitz et al., 2007) suggests that the TOR pathway controls mitochondrial respiration in yeast and that the harder mitochondria work, the longer yeast live.

Publication types

Comment

MeSH terms

Cell Respiration
Cellular Senescence / physiology*
Gene Expression Regulation, Fungal
Mitochondria / metabolism
Models, Biological
Protein Serine-Threonine Kinases
Reactive Oxygen Species / metabolism
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae / physiology
Saccharomyces cerevisiae Proteins / genetics
Saccharomyces cerevisiae Proteins / physiology*

Substances

Reactive Oxygen Species
Saccharomyces cerevisiae Proteins
Protein Serine-Threonine Kinases
target of rapamycin protein, S cerevisiae