This article makes some introductory comments on the histology of the skin and the pathophysiology of burn injury as these topics pertain to the estimation of the depth of the burn injury. The definition of a major burn and the salient points of its treatment are covered. In addition, some general comments are made about several special injuries for which burn center referral usually is sought. Finally, guidance is given in the selection and treatment of patients who have burns that may be treated on an outpatient basis.