The prognostic utility of stress imaging studies has been validated in numerous studies and, in general, patients with a normal imaging study have annual cardiac ischemic event rates of <1%. However, this predictive value of a normal stress imaging study does not appear to be applicable to subjects with diabetes. In this editorial, we summarize the current available data on prognostic utility of stress imaging studies in subjects with diabetes and provide insights into how to interpret and integrate these data for daily clinical practice. In conclusion, currently available data suggest that the prognostic value of stress imaging studies in subjects with diabetes differs from those without diabetes and should be interpreted as such.