Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation

Fabien Rebeaud; Stephan Hailfinger; Margot Thome

doi:10.1016/j.it.2007.03.004

Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation

Trends Immunol. 2007 May;28(5):196-200. doi: 10.1016/j.it.2007.03.004. Epub 2007 Mar 28.

Authors

Fabien Rebeaud¹, Stephan Hailfinger, Margot Thome

Affiliation

¹ Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.

PMID: 17395537
DOI: 10.1016/j.it.2007.03.004

Abstract

Mitogen-activated protein kinases (MAPKs), including p38 and c-Jun N-terminal kinase (JNK), have a key role in T cell receptor (TCR)-induced gene transcription but their precise mechanism of activation is not well understood. The findings of two recent papers provide new insight into the activation of p38 and JNK by the membrane-associated guanylate kinase (MAGUK) family members Dlgh1 and Carma1, respectively, and show how distinct MAGUK proteins control specific aspects of TCR-mediated MAPK activation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism*
Animals
Apoptosis Regulatory Proteins / metabolism*
CARD Signaling Adaptor Proteins / metabolism*
Cell Line
Discs Large Homolog 1 Protein
Enzyme Activation
Guanylate Kinases
Humans
MAP Kinase Kinase 4 / metabolism
Membrane Proteins / metabolism*
Mice
Mitogen-Activated Protein Kinases / metabolism*
Receptors, Antigen, T-Cell / metabolism*
Signal Transduction*
T-Lymphocytes / immunology
p38 Mitogen-Activated Protein Kinases / metabolism

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
CARD Signaling Adaptor Proteins
Card11 protein, mouse
Discs Large Homolog 1 Protein
Dlg1 protein, mouse
Membrane Proteins
Receptors, Antigen, T-Cell
Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
MAP Kinase Kinase 4
Guanylate Kinases