Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats

R Uribe-Escamilla; D Mota-Rojas; P Sánchez-Aparicio; M Alonso-Spilsbury; R González-Piña; A Alfaro-Rodríguez

doi:10.1016/j.seizure.2007.02.010

Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats

Seizure. 2007 Jul;16(5):397-401. doi: 10.1016/j.seizure.2007.02.010. Epub 2007 Mar 28.

Authors

R Uribe-Escamilla¹, D Mota-Rojas, P Sánchez-Aparicio, M Alonso-Spilsbury, R González-Piña, A Alfaro-Rodríguez

Affiliation

¹ Laboratory of Neurochemistry, National Institute of Rehabilitation, SSA, México City, Mexico.

PMID: 17395499
DOI: 10.1016/j.seizure.2007.02.010

Abstract

We studied the effects of high doses of pentobarbital (PB) and carbamazepine (CBZ) on electrolyte levels and pH in an epileptic animal model. Pentobarbital decreased Ca2+ and Na+ levels without pentylenetetrazole (PTZ). After this, Ca2+ and Na+ levels continued to decrease except when CBZ was used, which preserved the Ca2+ levels PTZ may have opposed effects on PB. Our results suggest that PB causes changes in electrolyte levels and pH, but these changes are diminished by CBZ.

MeSH terms

Animals
Anticonvulsants / pharmacology
Anticonvulsants / therapeutic use
Calcium / metabolism
Carbamazepine / pharmacology
Carbamazepine / therapeutic use
Disease Models, Animal
Drug Interactions
Electrolytes / metabolism*
Hydrogen-Ion Concentration / drug effects*
Hypnotics and Sedatives / pharmacology*
Hypnotics and Sedatives / therapeutic use
Male
Pentobarbital / pharmacology*
Pentobarbital / therapeutic use
Pentylenetetrazole
Rats
Rats, Wistar
Seizures / chemically induced
Seizures / drug therapy
Seizures / metabolism*
Sodium / metabolism
Statistics, Nonparametric

Substances

Anticonvulsants
Electrolytes
Hypnotics and Sedatives
Carbamazepine
Sodium
Pentobarbital
Calcium
Pentylenetetrazole