The constrained amino acid beta-Acc confers potency and selectivity to integrin ligands

Angew Chem Int Ed Engl. 2007;46(21):3976-8. doi: 10.1002/anie.200605248.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids / chemistry*
  • Cell Adhesion / drug effects
  • Cell Line
  • Cyclopropanes / chemistry*
  • Humans
  • Integrin alphaVbeta3 / chemistry*
  • K562 Cells
  • Ligands
  • Molecular Conformation
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Oligopeptides / pharmacology
  • Structure-Activity Relationship

Substances

  • Carboxylic Acids
  • Cyclopropanes
  • Integrin alphaVbeta3
  • Ligands
  • Oligopeptides
  • cis-beta-aminocyclopropanecarboxylic acid