How reliable are current docking approaches for structure-based drug design? Lessons from aldose reductase

Angew Chem Int Ed Engl. 2007;46(19):3575-8. doi: 10.1002/anie.200603625.
No abstract available

MeSH terms

  • Aldehyde Reductase / antagonists & inhibitors*
  • Aldehyde Reductase / metabolism
  • Binding Sites
  • Computer Simulation
  • Crystallography, X-Ray
  • Databases, Factual
  • Drug Design*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Ligands
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Ligands
  • Aldehyde Reductase