Antitumor efficacy of poly(dimer acid-dodecanedioic acid) copolymer in mice bearing Sarcoma-180 tumor

J Mater Sci Mater Med. 2007 Aug;18(8):1515-20. doi: 10.1007/s10856-007-0126-1. Epub 2007 Mar 27.

Abstract

The drug release profiles of poly(dimer acid-dodecanedioic acid) P(DA-DDDA) copolymer containing 5% adriamycin hydrochloride (ADM) in vitro were evaluated. The biocompatibility of P(DA-DDDA) under mice skin was also evaluated, macroscopic observation and microscopic analysis demonstrated that the copolymer is biocompatible and well tolerated in vivo. Antitumor efficacy of P(DA-DDDA) copolymers containing 5% adriamycin hydrochloride (ADM) implanted subcutaneously in mice bearing Sarcoma-180 tumor exhibited increased volume doubling time (VDT) (31 +/- 1.5 days) compared to plain subcutaneous injection of ADM (7 +/- 0.9 days). The studies suggest that P(DA-DDDA) copolymer as an effective carrier for antineoplastic drug like adriamycin hydrochloride has a very good prospect in the treatment of noumenon tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage*
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacokinetics
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Delayed-Action Preparations / administration & dosage*
  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / pharmacokinetics
  • Dicarboxylic Acids / administration & dosage*
  • Dicarboxylic Acids / chemistry
  • Dicarboxylic Acids / pharmacokinetics
  • Diffusion
  • Doxorubicin / administration & dosage*
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacokinetics
  • Drug Compounding / methods
  • Drug Implants
  • Injections, Subcutaneous
  • Materials Testing
  • Mice
  • Polymers / administration & dosage*
  • Polymers / chemistry
  • Polymers / pharmacokinetics
  • Sarcoma / drug therapy*
  • Sarcoma / pathology*
  • Treatment Outcome

Substances

  • Antibiotics, Antineoplastic
  • Delayed-Action Preparations
  • Dicarboxylic Acids
  • Drug Implants
  • Polymers
  • poly(dimer acid-dodecanedioic acid) copolymer
  • Doxorubicin