Mdm2: p53's lifesaver?

Mol Cell. 2007 Mar 23;25(6):794-6. doi: 10.1016/j.molcel.2007.03.006.

Abstract

In a recent issue of Molecular Cell, Taira et al. (2007) and Rinaldo et al. (2007) provide insight into the involvement of the DYRK2 kinase and a surprising role of MDM2 in regulation of DNA damage-induced apoptosis via p53 phosphorylation.

Publication types

  • Comment

MeSH terms

  • Apoptosis
  • Cell Division
  • DNA Damage*
  • Dyrk Kinases
  • Humans
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Phosphorylation
  • Protein Serine-Threonine Kinases / metabolism*
  • Protein-Tyrosine Kinases / metabolism*
  • Proto-Oncogene Proteins c-mdm2 / genetics*
  • Proto-Oncogene Proteins c-mdm2 / metabolism
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • Protein-Tyrosine Kinases
  • Protein Serine-Threonine Kinases