Abstract
In a recent issue of Molecular Cell, Taira et al. (2007) and Rinaldo et al. (2007) provide insight into the involvement of the DYRK2 kinase and a surprising role of MDM2 in regulation of DNA damage-induced apoptosis via p53 phosphorylation.
MeSH terms
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Apoptosis
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Cell Division
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DNA Damage*
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Dyrk Kinases
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Humans
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Neoplasms / genetics
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Neoplasms / pathology
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Phosphorylation
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Protein Serine-Threonine Kinases / metabolism*
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Protein-Tyrosine Kinases / metabolism*
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Proto-Oncogene Proteins c-mdm2 / genetics*
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Proto-Oncogene Proteins c-mdm2 / metabolism
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Tumor Suppressor Protein p53 / genetics*
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Tumor Suppressor Protein p53 / metabolism
Substances
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Tumor Suppressor Protein p53
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2
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Protein-Tyrosine Kinases
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Protein Serine-Threonine Kinases