Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation

Radiother Oncol. 2007 Apr;83(1):97-101. doi: 10.1016/j.radonc.2007.02.005. Epub 2007 Mar 26.

Abstract

The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT (213)Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.

MeSH terms

  • Alpha Particles
  • Antimetabolites, Antineoplastic / pharmacology
  • Cell Cycle / drug effects
  • Cell Cycle / radiation effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Proliferation / radiation effects
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / pharmacology
  • Gamma Rays
  • Gemcitabine
  • Humans
  • Linear Energy Transfer*
  • Multiple Myeloma / pathology
  • Multiple Myeloma / radiotherapy*
  • Radiation Dosage
  • Radiation Tolerance / drug effects*
  • Radiation-Sensitizing Agents / pharmacology*

Substances

  • Antimetabolites, Antineoplastic
  • Radiation-Sensitizing Agents
  • Deoxycytidine
  • Gemcitabine