Postoperative coagulopathy in a pediatric patient after exposure to bovine topical thrombin

Sheri S Crow; Vita V Sullivan; Agnes E Aysola; Nigel S Key; Paul Harker-Murray; John E Foker; Marie E Steiner

doi:10.1016/j.athoracsur.2006.10.079

Postoperative coagulopathy in a pediatric patient after exposure to bovine topical thrombin

Ann Thorac Surg. 2007 Apr;83(4):1547-9. doi: 10.1016/j.athoracsur.2006.10.079.

Authors

Sheri S Crow¹, Vita V Sullivan, Agnes E Aysola, Nigel S Key, Paul Harker-Murray, John E Foker, Marie E Steiner

Affiliation

¹ Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

PMID: 17383385
DOI: 10.1016/j.athoracsur.2006.10.079

Abstract

Severe postoperative coagulopathy developed in a child with congenital heart disease due to a factor V inhibitor from repetitive exposure to bovine topical thrombin. This case report alerts pediatric providers to consider these inhibitors when postoperative coagulopathy occurs. Potential treatment options are reviewed.

Publication types

Case Reports

MeSH terms

Administration, Topical
Animals
Blood Coagulation Disorders / etiology*
Blood Coagulation Disorders / physiopathology
Blood Coagulation Disorders / therapy
Blood Loss, Surgical / prevention & control
Blood Transfusion
Cardiac Surgical Procedures / adverse effects
Cardiac Surgical Procedures / methods
Cattle
Factor V / analysis*
Female
Follow-Up Studies
Heart Defects, Congenital / diagnosis
Heart Defects, Congenital / surgery
Hemostatic Techniques / adverse effects
Humans
Immunoglobulins / therapeutic use
Infant
Postoperative Complications / diagnosis
Postoperative Complications / therapy
Pulmonary Atresia / diagnosis
Pulmonary Atresia / surgery*
Risk Assessment
Thrombin / administration & dosage
Thrombin / adverse effects*

Substances

Immunoglobulins
Factor V
Thrombin