Iridoid glycosides from the stems of Pithecoctenium crucigerum (Bignoniaceae)

Frédéric Martin; Anne-Emmanuelle Hay; Laura Corno; Mahabir P Gupta; Kurt Hostettmann

doi:10.1016/j.phytochem.2007.02.002

Iridoid glycosides from the stems of Pithecoctenium crucigerum (Bignoniaceae)

Phytochemistry. 2007 May;68(9):1307-11. doi: 10.1016/j.phytochem.2007.02.002. Epub 2007 Mar 23.

Authors

Frédéric Martin¹, Anne-Emmanuelle Hay, Laura Corno, Mahabir P Gupta, Kurt Hostettmann

Affiliation

¹ Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.

PMID: 17382978
DOI: 10.1016/j.phytochem.2007.02.002

Abstract

Sixteen crude extracts from six Panamanian plants of the family Bignoniaceae were submitted to rapid TLC tests against DPPH and acetylcholinesterase. Pithecoctenium crucigerum (L.) A.H. Gentry, which showed interesting activity against DPPH, has been studied. The chemical investigation of the methanol extract from the stems afforded the iridoid glycoside theviridoside and three derivatives (6'-O-cyclopropanoyltheviridoside, 10-O-hydroxybenzoyltheviridoside and 10-O-vanilloyltheviridoside), along with five known phenylethanoid glycosides (verbascoside, isoverbascoside, forsythoside B, jionoside D and leucosceptoside B). These last compounds were all active against DPPH. The structures were determined by means of spectrometric and chemical methods, including 1D and 2D NMR experiments and MS analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bignoniaceae / chemistry*
Iridoids / chemistry*
Iridoids / isolation & purification*
Molecular Structure
Plant Stems / chemistry*

Substances

Iridoids