Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials

Randy Mellaerts; Caroline A Aerts; Jan Van Humbeeck; Patrick Augustijns; Guy Van den Mooter; Johan A Martens

doi:10.1039/b616746b

Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials

Chem Commun (Camb). 2007 Apr 7:(13):1375-7. doi: 10.1039/b616746b. Epub 2007 Jan 29.

Authors

Randy Mellaerts¹, Caroline A Aerts, Jan Van Humbeeck, Patrick Augustijns, Guy Van den Mooter, Johan A Martens

Affiliation

¹ Centre for Surface Chemistry and Catalysis, Kasteelpark Arenberg 23, Catholic University of Leuven, BE-3001, Heverlee, Belgium. johan.martens@biw.kuleuven.be.

PMID: 17377687
DOI: 10.1039/b616746b

Abstract

This in vitro study reports on the enhanced release of the hydrophobic drug itraconazole from the ordered mesoporous SBA-15 silica material and on the existence of a critical mesopore diameter for enhancing release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calorimetry, Differential Scanning
Itraconazole / chemistry*
Nitrogen / chemistry
Silicon Dioxide / chemistry*

Substances

SBA-15
Itraconazole
Silicon Dioxide
Nitrogen