Telomerase unplugged

Gaël Cristofari; Katarzyna Sikora; Joachim Lingner

doi:10.1021/cb700037c

Telomerase unplugged

ACS Chem Biol. 2007 Mar 20;2(3):155-8. doi: 10.1021/cb700037c.

Authors

Gaël Cristofari¹, Katarzyna Sikora, Joachim Lingner

Affiliation

¹ Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

PMID: 17373762
DOI: 10.1021/cb700037c

Abstract

The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Multiprotein Complexes / physiology
Shelterin Complex
Telomerase / metabolism*
Telomere-Binding Proteins / metabolism*
Telomere-Binding Proteins / physiology

Substances

ACD protein, human
Multiprotein Complexes
POT1 protein, human
Shelterin Complex
TINF2 protein, human
Telomere-Binding Proteins
Telomerase