Staphylococcus aureus strains that are hypersusceptible to resistance gene transfer from enterococci

Antimicrob Agents Chemother. 2007 Jun;51(6):2189-91. doi: 10.1128/AAC.01442-06. Epub 2007 Mar 19.

Abstract

We identified naturally occurring Staphylococcus aureus mutants of the restriction modification pathway SauI, including bovine lineage ST151. In a model of vancomycin resistance transfer from Enterococcus faecalis, ST151 isolates are 500 times more susceptible than human S. aureus isolates. The eradication of "hyperrecipient" strains may reduce the evolution of vancomycin-resistant S. aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Conjugation, Genetic*
  • Deoxyribonucleases, Type II Site-Specific / genetics
  • Enterococcus / drug effects
  • Enterococcus / genetics*
  • Female
  • Gene Transfer, Horizontal*
  • Humans
  • Mastitis, Bovine / microbiology
  • Molecular Sequence Data
  • Mutation
  • Sequence Analysis, DNA
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / veterinary
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / isolation & purification
  • Vancomycin Resistance / genetics*

Substances

  • Deoxyribonucleases, Type II Site-Specific
  • endodeoxyribonuclease SauI

Associated data

  • GENBANK/AJ938182