Abstract
The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Bacterial Proteins / genetics
-
Bacterial Proteins / metabolism
-
Biofilms / drug effects*
-
Biofilms / growth & development
-
Disease Models, Animal
-
Gene Expression Regulation, Bacterial
-
Methicillin Resistance*
-
Oligopeptides / administration & dosage
-
Oligopeptides / pharmacology*
-
Oligopeptides / therapeutic use*
-
Prosthesis-Related Infections / drug therapy*
-
Prosthesis-Related Infections / microbiology
-
Quorum Sensing / drug effects*
-
RNA-Binding Proteins / genetics
-
RNA-Binding Proteins / metabolism
-
Rats
-
Rats, Wistar
-
Staphylococcal Infections / drug therapy
-
Staphylococcal Infections / microbiology
-
Staphylococcus aureus / drug effects*
-
Staphylococcus aureus / genetics
-
Staphylococcus aureus / growth & development
-
Trans-Activators / genetics
-
Trans-Activators / metabolism
-
Transcription Factors / genetics
-
Transcription Factors / metabolism
-
Treatment Outcome
Substances
-
Agr protein, Staphylococcus aureus
-
Bacterial Proteins
-
MtrB protein, Bacteria
-
Oligopeptides
-
RNA-Binding Proteins
-
RNAIII inhibiting peptide
-
Trans-Activators
-
Transcription Factors