In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes

Antimicrob Agents Chemother. 2007 Jun;51(6):2219-22. doi: 10.1128/AAC.01382-06. Epub 2007 Mar 19.

Abstract

The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 microg/ml, respectively. MI was more active than ITC (P < 0.001).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Arthrodermataceae / classification
  • Arthrodermataceae / drug effects*
  • Cations / chemistry
  • Cations / pharmacology
  • Chlorides / chemistry
  • Chlorides / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / pharmacology
  • Pyridinium Compounds / chemistry
  • Pyridinium Compounds / pharmacology*
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / pharmacology*

Substances

  • Antifungal Agents
  • Cations
  • Chlorides
  • Pyridinium Compounds
  • Quaternary Ammonium Compounds
  • Phosphorylcholine
  • miltefosine