Abstract
In this study, we explored a convenient and concise route for synthesis of L-threo-sphingosine, D-threo-sphingosine, L-threo-sphinganine and D-threo-sphinganine from commercially available L- or D-serine. The key steps are the simple preparation of trans-oxazoline and intermolecular olefin cross metathesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Molecular Structure
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Oxazoles / chemistry*
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Protein Kinase C / antagonists & inhibitors*
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Protein Kinase Inhibitors* / chemical synthesis
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Protein Kinase Inhibitors* / chemistry
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Protein Kinase Inhibitors* / pharmacology
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Sphingosine / analogs & derivatives*
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Sphingosine / chemical synthesis
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Sphingosine / chemistry
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Sphingosine / pharmacology
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Alkenes
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Oxazoles
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Protein Kinase Inhibitors
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Protein Kinase C
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Sphingosine
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safingol