Abstract
Activity-guided fractionation of root and leaf extracts from Elephantopus mollis led to the isolation of a new triterpene (1) and a new sesquiterpene lactone (2) together with five known sesquiterpene lactones (3-7). The structures of compounds 1 and 2 were determined based on their spectroscopic data. The cytotoxic activity of the isolated compounds was evaluated against neuroblastoma B104 cells. The sesquiterpene lactone-type compounds 2-7 were highly cytotoxic. Among these, compound (5) was the most cytotoxic and induced apoptosis of neuroblastoma B104 cells in a dose- and time-dependent manner. No significant difference was observed for cytotoxicity of compound 5 towards all 3 cell lines tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Apoptosis / drug effects*
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Asteraceae*
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Cell Line, Tumor / drug effects
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Dose-Response Relationship, Drug
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Fibroblasts / drug effects
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Humans
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Lactones / administration & dosage
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Lactones / pharmacology
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Lactones / therapeutic use
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Mice
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Neuroblastoma / pathology
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Sesquiterpenes / administration & dosage
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use
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Triterpenes / administration & dosage
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Triterpenes / pharmacology
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Triterpenes / therapeutic use
Substances
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Antineoplastic Agents, Phytogenic
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Lactones
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Plant Extracts
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Sesquiterpenes
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Triterpenes