Sesquiterpene lactones from Saussurea alata

Nat Prod Res. 2007 Mar;21(3):221-6. doi: 10.1080/14786410601130752.

Abstract

Two new guaianolides, namely, 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11betaH)-12,6-olide (1) and 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11alphaH)-12,6-olide (2), together with six known guaianolides, 8-hydroxyzaluzanin C, austricin, chlorojanerin, cynaropicrin, chlorohyssopifolin E and chlorohyssopifolin A were isolated from the aerial parts of Saussurea alata. The structures were established mainly based on spectral analysis, especially 2D NMR techniques.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Screening Assays, Antitumor
  • Female
  • HeLa Cells
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Mass Spectrometry
  • Models, Molecular
  • Molecular Conformation
  • Saussurea / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes, Guaiane / chemistry*
  • Sesquiterpenes, Guaiane / isolation & purification
  • Spectrophotometry, Infrared
  • Stereoisomerism

Substances

  • 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11betaH)-12,6-olide
  • Lactones
  • Sesquiterpenes
  • Sesquiterpenes, Guaiane