Soluble Fas ligand: is it a critical mediator of toxic epidermal necrolysis and Stevens-Johnson syndrome?

Junko Murata; Riichiro Abe

doi:10.1038/sj.jid.5700693

Soluble Fas ligand: is it a critical mediator of toxic epidermal necrolysis and Stevens-Johnson syndrome?

J Invest Dermatol. 2007 Apr;127(4):744-5. doi: 10.1038/sj.jid.5700693.

Authors

Junko Murata¹, Riichiro Abe

Affiliation

¹ Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

PMID: 17363955
DOI: 10.1038/sj.jid.5700693

Abstract

Although soluble Fas ligand (sFasL) is an important candidate in toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), Stur and colleagues report that elevated sFasL has been detected in maculopapular rashes. In addition to sFasL, other factors, including predisposing genetic factors, should also be investigated to determine their precise pathogenesis in TEN and SJS.

Publication types

Comment
Editorial
Review

MeSH terms

Fas Ligand Protein / metabolism*
Humans
Stevens-Johnson Syndrome / etiology*

Substances

Fas Ligand Protein