Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy

ChemMedChem. 2007 Jun;2(6):806-10. doi: 10.1002/cmdc.200700014.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / chemical synthesis*
  • Antimalarials / therapeutic use
  • Binding, Competitive
  • Drug Delivery Systems*
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / therapeutic use
  • Escherichia coli Proteins / antagonists & inhibitors*
  • Escherichia coli Proteins / chemistry
  • Inorganic Pyrophosphatase / antagonists & inhibitors
  • Inorganic Pyrophosphatase / chemistry
  • Mevalonic Acid / chemistry*
  • Mevalonic Acid / metabolism
  • Phosphates / chemistry
  • Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors*
  • Phosphotransferases (Alcohol Group Acceptor) / chemistry
  • Terpenes / chemistry*
  • Terpenes / metabolism
  • Thermus thermophilus / enzymology
  • Transferases / antagonists & inhibitors
  • Transferases / chemistry

Substances

  • Antimalarials
  • Enzyme Inhibitors
  • Escherichia coli Proteins
  • Phosphates
  • Terpenes
  • Transferases
  • deoxyxylulose-5-phosphate synthase
  • Phosphotransferases (Alcohol Group Acceptor)
  • IspE protein, E coli
  • Inorganic Pyrophosphatase
  • Mevalonic Acid