Abstract
Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.
Publication types
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Clinical Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antigens, Bacterial / analysis
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Antigens, Bacterial / immunology*
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Bacterial Outer Membrane Proteins / analysis
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Bacterial Outer Membrane Proteins / immunology*
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Feasibility Studies
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Humans
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Lyme Disease / prevention & control*
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Lyme Disease Vaccines / immunology*
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Molecular Sequence Data
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Phylogeny*
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Lyme Disease Vaccines
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OspC protein