Objective: To evaluate the effects of the polypeptide growth factors on the periodontal ligament cell (PDLC) based on a comprehensive review on the literature concerned.
Methods: The recent literature related to the effects of the polypeptide growth factors on the PDLC were extensively and comprehensively reviewed and a corresponding evaluation was made.
Results: The proliferation and the multi-directional differentiation of the PDLC were found to be the basis for the regeneration of the periodontal tissues. The effects of the polypeptide growth factors on the function of the PDLC became a hot issue of the research on the regeneration of the periodontal tissues. The polypeptide growth factors were found to play an important role in the migration, growth, proliferation, differentiation, and synthesis of protein and matrix of the PDLC.
Conclusion: The polypeptide growth factors can be used in the periodontal regeneration treatment, but a further research is still required to improve this kind of treatment.