In Vitro activities of isepamicin, other aminoglycosides, and capreomycin against clinical isolates of rapidly growing mycobacteria in Taiwan

Antimicrob Agents Chemother. 2007 May;51(5):1849-51. doi: 10.1128/AAC.01551-06. Epub 2007 Mar 12.

Abstract

The in vitro activities of isepamicin against 117 Mycobacteria abscessus, 48 Mycobacterium fortuitum, and 20 Mycobacterium chelonae isolates were evaluated by a microdilution test. Isepamicin MIC(90)s were < or =16 microg/ml for the three species. Isepamicin was as active as amikacin and kanamycin and more active than tobramycin, capreomycin, gentamicin, and streptomycin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aminoglycosides / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Capreomycin / pharmacology*
  • Gentamicins / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium chelonae / drug effects
  • Mycobacterium fortuitum / drug effects
  • Nontuberculous Mycobacteria / drug effects*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Gentamicins
  • Capreomycin
  • isepamicin