Neoglycopeptide dendrimer libraries as a source of lectin binding ligands

Org Lett. 2007 Apr 12;9(8):1465-8. doi: 10.1021/ol070119d. Epub 2007 Mar 13.

Abstract

[structure: see text] A 15 625-membered peptide dendrimer combinatorial library was acylated with an alpha-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 (Fuc-alpha-CH2CO-Lys-Pro-Leu)4(Lys-Phe-Lys-Ile)2Lys-His-Ile-NH2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC50 = 11 microM) and Pseudomonas aeruginosa lectin PA-IIL (IC50 = 0.14 microM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Protein*
  • Dendrimers / chemistry*
  • Dendrimers / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • Fucose / chemistry
  • Glycopeptides / chemistry*
  • Glycopeptides / metabolism*
  • Lectins / metabolism*
  • Ligands
  • Molecular Structure
  • Protein Binding

Substances

  • Dendrimers
  • Glycopeptides
  • Lectins
  • Ligands
  • Fucose