Ménétrier's disease is an infrequent hypertrophic disease of the stomach associated with hypoproteinemia of unknown etiology. This disease is considered to be premalignant since 10-15% of affected individuals develop gastric cancer. We present a 66-year-old patient who had received a diagnosis of Ménétrier's disease 13 years previously and who was found to have advanced antral gastric cancer during follow-up. We provide an update on the optimal therapeutic approach, which has not been clearly defined to date.