Abstract
Bioassay-guided fractionation of the ethanol extract obtained from the fruits of Rheedia calcicola led to the isolation of two new guttiferone analogues, guttiferones K (1) and L (16-hydroxyguttiferone K) (2). The structures of 1 and 2 were established on the basis of extensive interpretation of one- and two-dimensional NMR spectroscopic data. Both compounds were tested for their antiproliferative activity against the A2780 human ovarian cancer cell line.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Benzophenones* / chemistry
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Benzophenones* / isolation & purification
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Benzophenones* / pharmacology
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Clusiaceae / chemistry*
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Drug Screening Assays, Antitumor
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Female
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Fruit / chemistry
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Humans
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Madagascar
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Benzophenones
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guttiferone K
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guttiferone L