Abstract
In order to compensate for the low partial pressure of oxygen at altitude, the human body undergoes a number of physiological changes. A vital component in this process is the increase in the concentration of circulating haemoglobin. The role of HIF-1alpha, erythropoietin and red blood cells in this acclimatisation process is described, together with the fall in plasma volume that increases the concentration of haemoglobin in the early stages of hypoxic exposure.
Publication types
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Historical Article
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Review
MeSH terms
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Acclimatization / physiology*
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Altitude Sickness / blood*
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Altitude Sickness / history
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Erythropoietin / physiology
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Hemoglobins / analysis
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Hemoglobins / physiology*
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History, 17th Century
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History, 18th Century
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History, 19th Century
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History, 20th Century
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / physiology
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Plasma Volume / physiology
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Polycythemia / blood
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Polycythemia / history
Substances
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Hemoglobins
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Hypoxia-Inducible Factor 1, alpha Subunit
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Erythropoietin