Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29

Alexandra Schosser; Karoline Fuchs; Theresa Scharl; Friedrich Leisch; Ursula Bailer; Siegfried Kasper; Werner Sieghart; Kurt Hornik; Harald N Aschauer

doi:10.1016/j.euroneuro.2007.01.004

Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29

Eur Neuropsychopharmacol. 2007 May-Jun;17(6-7):501-5. doi: 10.1016/j.euroneuro.2007.01.004. Epub 2007 Mar 6.

Authors

Alexandra Schosser¹, Karoline Fuchs, Theresa Scharl, Friedrich Leisch, Ursula Bailer, Siegfried Kasper, Werner Sieghart, Kurt Hornik, Harald N Aschauer

Affiliation

¹ Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Austria. alexandra.schosser@meduniwien.ac.at

PMID: 17344034
DOI: 10.1016/j.euroneuro.2007.01.004

Abstract

After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping*
Chromosomes, Human, Pair 3*
DNA Primers
Genetic Markers
Genotype
Humans
Polymorphism, Single Nucleotide*
Reproducibility of Results
Schizophrenia / genetics*
Telomere / genetics

Substances

DNA Primers
Genetic Markers