Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study

Clin Infect Dis. 2007 Apr 1;44(7):964-7. doi: 10.1086/512374. Epub 2007 Feb 14.

Abstract

We reviewed the records of 33 patients with leukemia who experienced influenza during the period from October 2000 to March 2004. Three (38%) of the 8 patients who did not receive neuraminidase inhibitor therapy and none of the 25 patients who received it died of influenza pneumonia (P=.001). The use of neuraminidase inhibitor therapy seems to improve the outcome of influenza in patients with leukemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antiviral Agents / therapeutic use*
  • Cohort Studies
  • Comorbidity
  • Female
  • Follow-Up Studies
  • Humans
  • Influenza, Human / diagnosis
  • Influenza, Human / drug therapy*
  • Influenza, Human / epidemiology*
  • Leukemia, Myeloid / diagnosis
  • Leukemia, Myeloid / epidemiology*
  • Male
  • Middle Aged
  • Neuraminidase / antagonists & inhibitors*
  • Neuraminidase / therapeutic use
  • Probability
  • Retrospective Studies
  • Risk Assessment
  • Survival Rate
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Neuraminidase