Analysis of substitution events in HIV-1 vif gene of the Korean clade

J Microbiol. 2007 Feb;45(1):75-8.

Abstract

Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent evolution in the Korean clade. At amino acid level, there were 17 substitutions and G-->E substitution at position 37 may be responsible for change in predicted secondary structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution
  • Asian People
  • Base Sequence
  • Consensus Sequence
  • Evolution, Molecular*
  • Gene Products, vif / chemistry
  • Gene Products, vif / genetics
  • Genes, vif*
  • HIV Infections / virology*
  • HIV-1 / classification
  • HIV-1 / genetics*
  • Humans
  • Molecular Sequence Data
  • Protein Structure, Secondary
  • Sequence Alignment
  • vif Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, vif
  • vif Gene Products, Human Immunodeficiency Virus