Abstract
Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent evolution in the Korean clade. At amino acid level, there were 17 substitutions and G-->E substitution at position 37 may be responsible for change in predicted secondary structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution
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Asian People
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Base Sequence
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Consensus Sequence
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Evolution, Molecular*
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Gene Products, vif / chemistry
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Gene Products, vif / genetics
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Genes, vif*
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HIV Infections / virology*
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HIV-1 / classification
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HIV-1 / genetics*
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Humans
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Molecular Sequence Data
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Protein Structure, Secondary
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Sequence Alignment
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vif Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, vif
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vif Gene Products, Human Immunodeficiency Virus