Sulfated triterpene derivatives from Fagonia arabica

J Nat Prod. 2007 Apr;70(4):584-8. doi: 10.1021/np060531m. Epub 2007 Mar 6.

Abstract

Two new sulfated triterpenes (1, 6) and four new sulfated triterpene glycosides (2-5) have been isolated from the aerial parts of Fagonia arabica. Their structures were established by spectroscopic data analysis. Compounds 1/2 and 3/4 are sulfated derivatives of the rare sapogenins 3beta,27-dihydroxyolean-12-en-28-oic acid and 3beta,27-dihydroxyurs-12-en-28-oic acid, respectively. Compound 5 is an unusual disulfated oleanene derivative characterized by the occurrence of a 13,18-double bond, while compound 6 is the first reported naturally occurring saturated and sulfated pentacyclic triterpene of the taraxastane series with a C-20,28 lactone unit.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Screening Assays, Antitumor
  • Egypt
  • Humans
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Sulfuric Acid Esters / chemistry
  • Sulfuric Acid Esters / isolation & purification*
  • Sulfuric Acid Esters / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Zygophyllaceae / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Sulfuric Acid Esters
  • Triterpenes