Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis

J Neurol Sci. 2007 Apr 15;255(1-2):50-6. doi: 10.1016/j.jns.2007.01.069. Epub 2007 Mar 6.

Abstract

Frontal-subcortical abnormalities have been implicated in the pathophysiology of Tourette syndrome (TS). The goal of this study was to more extensively evaluate a possible underlying neurochemical abnormality in frontal cortex. Postmortem brain tissue from frontal and occipital regions (Brodmann's areas 4, 6, 9, 10, 11, 12, and 17) from three TS patients and three age-and sex-matched controls were analyzed by semiquantitative immunoblotting. Relative densities were measured for a variety of neurochemical markers including dopamine (D1, D2), serotonin (5HT-1A), and alpha-adrenergic (alpha-2A) receptors, the dopamine transporter (DAT), a monoamine terminal marker (vesicular monoamine transporter type 2, VMAT-2), and vesicular docking and release proteins (VAMP-2, synaptotagmin, SNAP-25, syntaxin, synaptophysin). Data from each TS sample, corrected for actin content, was expressed as a percentage value of its control. Results identified consistent increases of DAT and D2 receptor density in five of six frontal regions in all three TS subjects. D1 and alpha-2A receptor density were increased in a few frontal regions. These results support the hypothesis of a dopaminergic dysfunction in the frontal lobe and a likely role in the pathophysiology of TS.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Brain Chemistry / physiology
  • Dopamine / analysis
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins / analysis
  • Dopamine Plasma Membrane Transport Proteins / metabolism
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / analysis
  • Nerve Tissue Proteins / metabolism
  • Predictive Value of Tests
  • Prefrontal Cortex / metabolism*
  • Prefrontal Cortex / pathology*
  • Receptors, Dopamine D2 / analysis
  • Receptors, Dopamine D2 / metabolism
  • Reference Values
  • Synaptic Membranes / metabolism
  • Synaptic Vesicles / metabolism
  • Tourette Syndrome / metabolism*
  • Tourette Syndrome / pathology*
  • Up-Regulation / physiology

Substances

  • Biomarkers
  • Dopamine Plasma Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Receptors, Dopamine D2
  • Dopamine