Abstract
Administration of the aqueous extract of Mitragyna speciosa at a dose of 300 mg/kg significantly inhibited ethanol withdrawal-induced behaviors that included rearing, displacement and head weaving. The results also showed that at doses of 100, 300 and 500 mg/kg M. speciosa showed antidepressant activity without effect on the spontaneous motor activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / administration & dosage
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Analgesics / pharmacology*
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Analgesics / therapeutic use
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Animals
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Behavior, Animal / drug effects
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Dose-Response Relationship, Drug
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Ethanol / adverse effects
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Male
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Mice
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Mitragyna*
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Pain / chemically induced
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Pain / prevention & control*
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Pain Measurement / drug effects
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
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Substance Withdrawal Syndrome / pathology
Substances
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Analgesics
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Plant Extracts
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Ethanol