Abstract
We present here the first data available on resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in India. In these subtype C isolates, we have observed most of the mutations noted in reverse transcriptase (RT) for subtype B with some additional substitutions (at positions 98, 203, 208, and 221) that will warrant attention in the algorithms used.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antiretroviral Therapy, Highly Active*
-
Drug Resistance, Viral / genetics*
-
HIV Infections / drug therapy*
-
HIV Infections / genetics
-
HIV-1 / classification
-
HIV-1 / drug effects*
-
HIV-1 / genetics
-
Humans
-
India
-
Mutation / genetics
-
Polymorphism, Genetic / genetics
-
RNA-Directed DNA Polymerase / genetics*
-
Reverse Transcriptase Inhibitors / pharmacology*
-
Treatment Failure
Substances
-
Reverse Transcriptase Inhibitors
-
RNA-Directed DNA Polymerase