Resistance mutations in subtype C HIV type 1 isolates from Indian patients of Mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: resistance to AR

AIDS Res Hum Retroviruses. 2007 Feb;23(2):335-40. doi: 10.1089/aid.2006.0183.

Abstract

We present here the first data available on resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in India. In these subtype C isolates, we have observed most of the mutations noted in reverse transcriptase (RT) for subtype B with some additional substitutions (at positions 98, 203, 208, and 221) that will warrant attention in the algorithms used.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiretroviral Therapy, Highly Active*
  • Drug Resistance, Viral / genetics*
  • HIV Infections / drug therapy*
  • HIV Infections / genetics
  • HIV-1 / classification
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • Humans
  • India
  • Mutation / genetics
  • Polymorphism, Genetic / genetics
  • RNA-Directed DNA Polymerase / genetics*
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Treatment Failure

Substances

  • Reverse Transcriptase Inhibitors
  • RNA-Directed DNA Polymerase