Catalytic activity of silica gels bound manganese(III)-porphyrin on oxidative reaction of adrenaline

Youji Kitamura; Tsutomu Takatsuki; Mayu Kawamoto; Madoka Saito; Akimasa Iwado; Ikuko Tsukamoto; Masaki Mifune; Yutaka Saito

doi:10.1248/cpb.55.500

Catalytic activity of silica gels bound manganese(III)-porphyrin on oxidative reaction of adrenaline

Chem Pharm Bull (Tokyo). 2007 Mar;55(3):500-2. doi: 10.1248/cpb.55.500.

Authors

Youji Kitamura¹, Tsutomu Takatsuki, Mayu Kawamoto, Madoka Saito, Akimasa Iwado, Ikuko Tsukamoto, Masaki Mifune, Yutaka Saito

Affiliation

¹ Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University, Tsushima-Naka, Okayama, Japan.

PMID: 17329903
DOI: 10.1248/cpb.55.500

Abstract

To develop a solid catalysis on oxidative reaction of adrenaline (Ad), supports bound metal-tetrakis(4-carboxyphenyl)porphine (M-TCPP) were investigated. Silica gels bound Mn-TCPP were proved to has a superior activity in the oxidation of Ad and be able to serve as a useful oxidase model for Ad.

MeSH terms

Catalysis
Epinephrine / chemistry*
Hematoporphyrins / chemistry*
Metalloporphyrins / chemistry*
Molecular Structure
Oxidation-Reduction
Silica Gel
Silicon Dioxide / chemistry*

Substances

Hematoporphyrins
Metalloporphyrins
Silica Gel
manganese (III) hematoporphyrin
Silicon Dioxide
Epinephrine