Bradycardia can induce increased serum natriuretic peptide-level

Tímea Kováts; András Wettstein; Erzsébet Nagy; János Tomcsányi

doi:10.1016/j.ijcard.2006.11.144

Bradycardia can induce increased serum natriuretic peptide-level

Int J Cardiol. 2008 Jan 11;123(2):e43-4. doi: 10.1016/j.ijcard.2006.11.144. Epub 2007 Feb 27.

Authors

Tímea Kováts, András Wettstein, Erzsébet Nagy, János Tomcsányi

PMID: 17328978
DOI: 10.1016/j.ijcard.2006.11.144

Abstract

Here we report a case of an elderly woman whose antihypertensive beta-blocker therapy induced sinus arrest with a 40 bpm junctional escape rhythm. Although there was no sign of heart failure during bradycardia, a highly elevated amino-terminal pro-brain natriuretic peptide (NT-proBNP) serum level was detected. Cessation of the beta-blocker agent resulted in normal sinus rhythm and a rapid fall in the NT-proBNP serum level. As a rare phenomenon, bradycardia-related cardiomyopathy is discussed.

Publication types

Case Reports
Letter

MeSH terms

Adrenergic beta-Antagonists / adverse effects
Aged, 80 and over
Bradycardia / blood*
Bradycardia / chemically induced
Female
Humans
Natriuretic Peptide, Brain / blood*
Natriuretic Peptides / blood*
Peptide Fragments / blood*
Protein Precursors / blood*

Substances

Adrenergic beta-Antagonists
Natriuretic Peptides
Peptide Fragments
Protein Precursors
pro-brain natriuretic peptide (1-76)
Natriuretic Peptide, Brain