In patients who have undergone surgery and radiotherapy for oral squamous cell carcinoma (OSCC), the posterior oral rehabilitation may prove complex. In addition to the defects produced by surgical ablation of the primary tumor, radiotherapy induces deleterious effects upon the oral tissues. We present the case of a 48-year-old male treated two years before due to OSCC in the retromolar trigone and left lateral wall of the oropharynx. Following study of the case with clinical examination and orthopantomography, a management plan was defined involving rehabilitation of the upper dental arch with fixed ceramometallic prostheses, while in the lower arch we chose a unilateral removable prosthesis adapted to a fixed prosthesis by means of a special and versatile attachment based on a new system that functions as a fixed element but which can be removed or changed at some later date. The present clinical case illustrates this type of prosthodontic solution for the management of oncological patients of this kind.