A 32-yr-old white-throated capuchin monkey (Cebus capucinus) was presented for paraparesis. A diagnosis of protozoal meningitis was made on the basis of a lymphocytic pleocytosis with elevated protein in cerebrospinal fluid and a positive serum titer to Toxoplasma gondii of 131,072 using an indirect hemagglutination test. Treatment with clindamycin and trimethaprim-sulfamethoxazole resulted in improvement within 3 days and complete clinical resolution within 2 wk.