Antitubercular dihydroagarofuranoid sesquiterpenes from the roots of Microtropis fokienensis

Jih-Jung Chen; Tsung-Hsien Chou; Chien-Fang Peng; Ih-Sheng Chen; Sheng-Zehn Yang

doi:10.1021/np060500r

Antitubercular dihydroagarofuranoid sesquiterpenes from the roots of Microtropis fokienensis

J Nat Prod. 2007 Feb;70(2):202-5. doi: 10.1021/np060500r.

Authors

Jih-Jung Chen¹, Tsung-Hsien Chou, Chien-Fang Peng, Ih-Sheng Chen, Sheng-Zehn Yang

Affiliation

¹ Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, Republic of China. jjchen@mail.tajen.edu.tw

PMID: 17315960
DOI: 10.1021/np060500r

Abstract

Four new dihydroagarofuranoid sesquiterpenes (1-4) and a new hydroxybenzylsalicylaldehyde, forkienin (5), together with nine known compounds have been isolated from the roots of Microtropis fokienensis. The structures of the new compounds were determined through analyses of physical data. Compounds 3, 4, 7, and 8 exhibited potent antitubercular activities (MICs < or = 26.0 microM) against Mycobacterium tuberculosis 90-221387 in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents* / chemistry
Antitubercular Agents* / isolation & purification
Antitubercular Agents* / pharmacology
Celastraceae / chemistry*
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Sesquiterpenes* / chemistry
Sesquiterpenes* / isolation & purification
Sesquiterpenes* / pharmacology
Taiwan

Substances

Antitubercular Agents
Sesquiterpenes