New C-3' hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents

Org Biomol Chem. 2006 Nov 21;4(22):4178-85. doi: 10.1039/b612475e.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus subtilis / drug effects*
  • Cephalosporins / chemical synthesis
  • Cephalosporins / chemistry
  • Cephalosporins / pharmacology*
  • Chlorocebus aethiops
  • Cyclization
  • Hydroxamic Acids / chemistry
  • Microbial Sensitivity Tests
  • Micrococcus luteus / drug effects*
  • Molecular Conformation
  • Mycobacterium tuberculosis / drug effects*
  • Staphylococcus aureus / drug effects*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Vero Cells / drug effects

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Hydroxamic Acids