Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading

Org Biomol Chem. 2006 Nov 21;4(22):4149-57. doi: 10.1039/b609143a.

Abstract

We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Benzazepines / chemical synthesis*
  • Benzazepines / chemistry
  • Benzazepines / pharmacology*
  • Cell Proliferation / drug effects
  • Cell Shape / drug effects
  • Dose-Response Relationship, Drug
  • Epithelial Cells / cytology
  • Epithelial Cells / drug effects*
  • Kidney / cytology
  • Kidney / drug effects
  • Macaca mulatta
  • Molecular Structure
  • Oximes / chemical synthesis*
  • Oximes / chemistry
  • Oximes / pharmacology*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Time Factors
  • cdc42 GTP-Binding Protein / antagonists & inhibitors*

Substances

  • Benzazepines
  • Oximes
  • secramine A
  • cdc42 GTP-Binding Protein