Abstract
We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Benzazepines / chemical synthesis*
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Benzazepines / chemistry
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Benzazepines / pharmacology*
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Cell Proliferation / drug effects
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Cell Shape / drug effects
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Dose-Response Relationship, Drug
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Epithelial Cells / cytology
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Epithelial Cells / drug effects*
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Kidney / cytology
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Kidney / drug effects
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Macaca mulatta
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Molecular Structure
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Oximes / chemical synthesis*
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Oximes / chemistry
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Oximes / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
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Time Factors
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cdc42 GTP-Binding Protein / antagonists & inhibitors*
Substances
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Benzazepines
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Oximes
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secramine A
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cdc42 GTP-Binding Protein