Although many papers had described the role of colo-rectal adenomas and the risk for colon cancer, there is a lack of data about epidemiological factors, the histological type, the pit-pattern and type of polyps in Romania. In polypoid adenomas the risk of malignant transformation is well known and is increasing over time, with size and villous architecture. In this paper we evaluate the predictive parameters that allowed us to establish a correlation between the macroscopical aspect and histological architecture of adenomas in our geographical area (South-West region of Romania). Two predictive parameters of cancer characterize early neoplastic lesions: their size and their surface elevation (elevated, flat or depressed). The morphology of adenomas and multiplicity of polyps also have a prognostic value. In our study the main localization of polyps was in the left colon, while the main histological type was tubulo-villous adenomas. We consider that the significant parameters for dysplasia and malignant lesions are the size of lesions, multiplicity of polyps and villous architecture.