Design and synthesis of metal-free artificial ribonucleases

Protein Pept Lett. 2007;14(2):151-63. doi: 10.2174/092986607779816177.

Abstract

The present review is aimed at giving a general overview of our results in the field of designing and synthesizing simple peptide-like molecules that mimic structural and functional aspects of natural ribonucleases, as well as designing oligonucleotide-based artificial ribonucleases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Metals / chemistry
  • Models, Molecular
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Oligonucleotides / chemistry
  • Oligonucleotides / metabolism
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • RNA / chemistry
  • RNA / metabolism
  • Ribonucleases / chemical synthesis*
  • Ribonucleases / chemistry
  • Ribonucleases / metabolism
  • Substrate Specificity

Substances

  • Metals
  • Oligonucleotides
  • Peptides
  • RNA
  • Ribonucleases