N-methylimidazole significantly improves lipase-catalysed acylation of ribavirin

Chem Commun (Camb). 2007 Jan 21:(3):295-7. doi: 10.1039/b611454g. Epub 2006 Oct 27.

Abstract

N-methylimidazole, a molecular solvent, but also, in cationic form, a component of 1-alkyl-3-methylimidazolium ([C(n)MIM]+) ionic liquids, showed promise as an additive in accelerating remarkably transesterification catalyzed by lipase acrylic resin from Candida antarctica (CAL-B).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation / drug effects
  • Anions / chemistry
  • Candida / enzymology
  • Catalysis / drug effects
  • Imidazoles / pharmacology*
  • Ionic Liquids
  • Lipase / metabolism*
  • Molecular Structure
  • Ribavirin / chemistry*
  • Ribavirin / metabolism*

Substances

  • Anions
  • Imidazoles
  • Ionic Liquids
  • Ribavirin
  • Lipase
  • 1-methylimidazole