Prothrombotic coagulation abnormalities in patients with newly diagnosed multiple myeloma

Haematologica. 2007 Feb;92(2):279-80. doi: 10.3324/haematol.10454.

Abstract

Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor (vWF) and a decrease in protein S were observed and these changes were strongly associated with disease stage. No difference in baseline coagulation parameters was found between patients with and without subsequent venous thromboembolism.

Publication types

  • Letter

MeSH terms

  • Aged
  • Antibodies, Antiphospholipid / chemistry
  • Blood Coagulation Disorders / complications*
  • Blood Coagulation Disorders / diagnosis*
  • Blood Coagulation*
  • Case-Control Studies
  • Factor VIII / biosynthesis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma / blood*
  • Multiple Myeloma / diagnosis*
  • Protein S / biosynthesis
  • Venous Thrombosis / complications*
  • Venous Thrombosis / diagnosis*
  • von Willebrand Factor / biosynthesis

Substances

  • Antibodies, Antiphospholipid
  • Protein S
  • von Willebrand Factor
  • Factor VIII