Abstract
We explored the role of interleukin-7 (IL-7) in the bone marrow (BM) stroma-mediated survival of primary T-cell acute lymphoblastic leukemia (T-ALL) cells and normal thymocytes. We presented evidence that IL-7 has a major role in the enhanced survival mediated by BM stroma both in T-ALL cells and thymocytes.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Marrow Cells / cytology*
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Cell Proliferation
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Cell Survival
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Child
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Child, Preschool
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Coculture Techniques
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Flow Cytometry
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Humans
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Infant
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Interleukin-7 / biosynthesis
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Interleukin-7 / physiology*
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Lymphopoiesis
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Mice
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*
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Thymus Gland / cytology*
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Thymus Gland / metabolism