In this study we analyzed variables related to the consumption of alcohol and other psychoactive substances among young people, and to their attitudes towards experimentation. The sample was made up of 775 pupils aged 12 to 16 from four secondary schools in the Principality of Asturias (northern Spain). The results obtained confirm the multi-causal nature of these phenomena. The attitudes of young people towards substance use was found to be more favourable the lower the perception of risk, the more mistaken their beliefs and the more permissive their disposition to the use of alcohol and other illegal drug. Other determining factors are their relationship with peer groups that use drugs, antisocial behaviours and attention-seeking indications.